PLINEST® is the first original Polynucleotides (PN) in the market. It is bio-compatible with human DNA, and they have excellent safety profile certified by the CE mark by the European Union since 2005.

What is Plinest

PLINEST® is made from Polynucleotides (PN), a DNA fragment extracted from Italian Trout Fish using patented extraction and purification process, HPTTM (Highly Purified Technology) by Mastelli, Italy.

70 years of long research was done in order to obtain a pure ingredient without pharmacologically and allergically active protein contaminants, resulting in excellent safety and superior efficacy of the product.

What is Polynucleotide

Polynucleotide is a type of biomolecule that consists of a long chain of nucleotides. Nucleotides are the building blocks of DNA and RNA.

Polynucleotide is typically used in cosmetic and medical treatments to promote skin regeneration, improve texture, and enhance overall skin health.

How does it work

PLINEST® increases fibroblast growth and vitality, helping stimulate collagen fibers productions and tissue repair. They increase 60% of collagen I & III and 35% of fibronectin production, which is a connective tissue that helps to firm the skin and aid in wound healing process. 

Can Plinest be combined with other treatments?

Yes! PLINEST® can be safely combined with other aesthetic treatments such as laser, HIFU, fillers, and BOTOX. Clinical studies have proven that PLINEST® can significantly improve the outcome of these aesthetic treatments.


PLINEST® is clinically proven to improve overall skin health from within by:

⦁ Promoting bio-revitalisation to reverse signs of aging
⦁ Regenerating fibroblast and collagen to repair damaged skin
⦁ Improving hydration and elasticity
⦁ Restoring glowing skin radiance and youthfulness

Treatment Protocol

For the first 3 sessions of PLINEST® treatment, it is advisable to administer the treatments 1 month apart. After completing the initial treatment, it is recommended to repeat the sessions after 3 to 6 months depending on the skin condition.

Generally, PLINEST® can last for up to 6 months, however it depends on the patient’s skin condition, lifestyle and environment factors as well.

Plinest vs Rejuran


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