Profhilo, Plinest and Skin Boosters – Which Injectable Treatment is the best?


It is time to think about something that goes a bit deeper into the skin—injectable treatments. If you have dry skin, wrinkles, fine lines, and huge pores that don’t appear to be getting better with skin care, then this may interest you.

“Doctor, which injectable treatment is the best”? is a question I get asked a lot. We discussed Profhilo and Plinest previously, so let’s take those and compare them with the addition of Skin Boosters.

The following are the similarities between Profhilo, Plinest, and Skin Boosters:

⦁ They are all injectable treatments.
⦁ They can help skin that is dry, wrinkly and crepey.
⦁ They are not dermal fillers; therefore, they do not fill or volumize any areas of the face.
⦁ They are not Botox (botulinum toxin A). As a fact, they do not aid in wrinkle reduction or muscle relaxation.

Is Profhilo therefore superior to Plinest? Are Skin Boosters superior to Profhilo? Is Plinest superior to Skin Boosters? What is then the best treatment?
In actuality, there is no correct response to this query.

The correct question should be, “Which injectable treatment works best for me?”
Profhilo, Plinest & Skin Boosters have been proven to be effective and can provide significant results if administered properly. However, it is critical to determine which treatment is best suited to a patient’s needs and concerns based on skin condition. Despite the fact that all three treatments aim to improve skin quality, their primary function and treatment protocol are quite different.


Skinboosters involve multiple microinjections of pure hyaluronic acid into the skin to promote skin hydration. Generally, the products used include Juvederm Volite, Teosyal Redensity I, and Restylane Skinbooster. Skinboosters require at least 3 sessions with one month interval in order to achieve longer-lasting results. It is followed by maintenance every 6-12 months, depending on the condition of the skin.

Skinboosters are particularly beneficial for patients who desire to increase skin moisture as well as glow and luminosity. Skinboosters can be combined with microbotox to tighten the pores and control oil production. In comparison to Profhilo and Plinest, skinboosters have far less of a reparative and lifting effect on the skin.


Plinest is made from polynucleotide (PN), a DNA fragment extracted from Italian trout using patented technology (Highly Purified Technology). Plinest encourages bio-revitalization in order to reverse the signs of ageing and regenerate fibroblast and collagen in order to repair damaged skin. Newest contains hyaluronic acid (HA), which is why it has skin-hydrating properties. 

There are different types of Plinest injections, namely:

⦁ Plinest – contains a high concentration of PN
⦁ Newest – includes PN & HA
⦁ Plinest Fast – for rejuvenation of the eyes and lips
⦁ Plinest One – for stretch marks on the body
⦁ Newest One – for stretch marks on the body

Plinest can be administered by using multiple microinjections or cannula technique. Similar to skin boosters, the recommended treatment plan calls for 3 treatments with one month interval, followed by maintenance treatment 6-12 months thereafter.

Plinest works well for treating acne scars, open pores, fine lines & wrinkles, sensitive skin. It also improves skin moisture. Plinest has stronger healing and collagen-building properties than skinboosters and Profhilo. In terms of hydration benefits, it is not as pronounced as Profhilo or skinboosters.


Profhilo contains the highest concentration of HA. It consists of both high- and low-molecular-weight HA, which work together to bio-remodel the skin by promoting the production of 4 types of collagen and elastin, which have the lifting, firming, anti-aging and hydrating properties. Profhilo only requires 5 injection points (Bio Aesthetic Points) for each side of the face, reducing the risk of bruising or injuries to vital structures. Therefore, compared to Plinest and skinboosters, Profhilo is the fastest, requires the fewest injections, and, as a result, has the least downtime. The recommended treatment protocol for Profhilo is 2 treatments with one month apart. Third session is required for those with severe skin laxity.

Patients with skin dryness and laxity will benefit the most from Profhilo treatment. The hydrating and bio-remodeling benefits of Profhilo are superior than skinboosters and Plinest. However, if you have dry skin and fine wrinkles over your forehead and under eyes, Plinest or skinboosters will work best for you.


Hence, the best treatment for you depends on your skin concern and the outcome you desire. There is never a ‘one size fits all’ solution in our aesthetic practice. What is ideal for one patient may not be ideal for another.

The majority of people usually go for the ‘more popular product’ on the market. They fail to understand, though, that ‘the more popular product’ does not always imply that it is best for their skin. To choose the best course of action, it is crucial to speak with a skilled aesthetic physician about your concerns and skin condition.